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humans ireland female male metabolism animals adult physiology chemistry genetics middle aged education aged pathology psychology follow up drug effects pharmacology training Follow-Up Studies diagnosis time factors up-regulation medicine and health sciences adolescent epidemiology therapy surgery physiopathology therapeutic use treatment outcome irish prevention & control standards risk factors etiology drug therapy cattle prospective studies mice aged, 80 and over young adult blood questionnaires child immunology instrumentation pregnancy biosynthesis microbiology statistics & numerical data gene expression machine translating physics complications adverse effects algorithms history cytology cell line information retrieval computer science administration & dosage growth & development reproducibility of results machine learning cells, cultured rats retrospective studies management sociology electronic engineering isolation & purification mechanical engineering prognosis