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humans female animals male metabolism drug effects pharmacology physiology drug therapy adult therapeutic use genetics therapy middle aged treatment outcome chemistry pathology ireland aged diagnosis blood physiopathology administration & dosage surgery cattle adverse effects mice etiology microbiology time factors psychology prevention & control epidemiology medicine and health sciences immunology complications apoptosis antagonists & inhibitors cytology adolescent rats risk factors this review veterinary biosynthesis cell line growth & development pregnancy aged, 80 and over cell line, tumor child gene expression cells, cultured antineoplastic agents cell proliferation isolation & purification breast neoplasms prospective studies signal transduction statistics & numerical data analogs & derivatives enzymology young adult cancer cell survival prognosis retrospective studies dose-response relationship, drug Follow-Up Studies mortality toxicity quality of life follow up disease models, animal