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humans animals ireland metabolism female physiology literature review genetics male chemistry therapeutic use systematic review therapy pathology diagnosis education adult drug therapy etiology epidemiology physiopathology psychology prevention & control adverse effects aged middle aged literature risk factors pharmacology drug effects microbiology immunology signal transduction surgery complications pregnancy future standards irish meta-analysis statistics & numerical data retrospective studies treatment outcome medicine and health sciences adolescent child administration & dosage management history brain apoptosis models, biological organization & administration risk assessment randomized controlled trials as topic patients economics neoplasms blood classification randomised controlled trials treatment data collection decision making inflammation instrumentation engineering nursing aged, 80 and over clinical practice clinical trials immune system recent developments prognosis