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chemistry humans animals female ireland particle size metabolism physiology male genetics drug effects cattle Sample Size pathology pharmacology adult nanoparticles surface properties middle aged physics blood aged ultrastructure mechanical engineering instrumentation irish materials computer science physiopathology time factors x-ray diffraction water cytology algorithms risk factors administration & dosage pregnancy isolation & purification mice computer simulation psychology therapy Organ Size growth & development materials testing anatomy & histology epidemiology porosity veterinary etiology microbiology nanotechnology size distribution tissue engineering management diagnosis proteins reproducibility of results biotechnology large-scale adverse effects nanoscience & materials rats adolescent nanostructures models, biological this review aged, 80 and over economics electronic engineering immunology surgery body size cell line