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humans animals female metabolism male chemistry genetics physiology pharmacology ireland drug effects adult middle aged cattle pathology aged therapeutic use drug therapy microbiology blood therapy mice psychology administration & dosage prevention & control physiopathology rats isolation & purification pregnancy time factors adverse effects random allocation diagnosis veterinary epidemiology immunology classification adolescent etiology growth & development medicine and health sciences this review antagonists & inhibitors biosynthesis treatment outcome gene expression standards risk factors randomized controlled trials as topic algorithms education analogs & derivatives information retrieval computer science cytology questionnaires sensitivity and specificity surgery aged, 80 and over enzymology cell line, tumor molecular sequence data instrumentation statistics & numerical data young adult biotechnology apoptosis escherichia coli systematic review meta-analysis milk reproducibility of results cell line physics complications