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humans female animals male metabolism chemistry physiology genetics adult ireland drug effects pharmacology middle aged pathology aged education psychology computer science diagnosis algorithms mice electronic engineering physiopathology blood adolescent cattle instrumentation immunology information retrieval sensitivity and specificity surgery young adult rats microbiology physics medicine and health sciences pregnancy drug therapy reproducibility of results administration & dosage time factors therapeutic use etiology cytology image processing adverse effects real-time biosynthesis prevention & control standards therapy cell line gene expression mechanical engineering complications epidemiology growth & development classification cells, cultured isolation & purification signal transduction enzymology this review brain engineering statistics & numerical data aged, 80 and over prospective studies machine learning antagonists & inhibitors biotechnology computer simulation environment risk factors irish