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metabolism animals chemistry humans pharmacology drug effects physiology female male cattle hydrogen-ion concentration blood genetics ireland growth & development time factors microbiology adult administration & dosage isolation & purification enzymology rats veterinary pregnancy immunology pathology kinetics analogs & derivatives cytology dose-response relationship, drug middle aged biosynthesis mice milk toxicity antagonists & inhibitors cell line water progesterone drug therapy physics physiopathology biotechnology lactation prevention & control cell line, tumor fatty acids chromatography, high pressure liquid diet environmental monitoring escherichia coli adverse effects aged cell survival cells, cultured sensitivity and specificity apoptosis models, biological therapeutic use instrumentation reproducibility of results pharmacokinetics calcium rats, wistar Animal Feed body weight chemical synthesis particle size dietary supplements oxygen risk factors secretion signal transduction standards estradiol