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humans female male animals ireland metabolism chemistry standards adult genetics physiology middle aged pharmacology drug effects aged psychology diagnosis pathology microbiology blood cattle epidemiology education medicine and health sciences adolescent isolation & purification prevention & control computer science therapy algorithms drug therapy sensitivity and specificity questionnaires risk factors physiopathology irish reproducibility of results immunology statistics & numerical data therapeutic use electronic engineering time factors young adult instrumentation etiology aged, 80 and over economics mice classification this review administration & dosage cytology gene expression adverse effects veterinary pregnancy complications child surgery rats mathematics physics enzymology cell line information retrieval growth & development non-linear biosynthesis prospective studies antagonists & inhibitors biotechnology image processing real-time treatment outcome organization & administration