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humans animals metabolism female immunology physiology genetics male drug effects mice pharmacology physiopathology blood pathology chemistry middle aged adult aged apoptosis bordetella pertussis cystic fibrosis inflammation microbiology therapeutic use administration & dosage drug therapy immune system phagocytosis disease models, animal immune response ireland macrophages signal transduction this review Metabolic Clearance Rate neutrophils pharmacokinetics th1 cells therapy biochemistry epithelial cells medicine and health sciences time factors anti-inflammatory cattle cell line complications cytology dendritic cells epidemiology lung prospective studies reactive oxygen species adverse effects biosynthesis brain creatinine dogs etiology Fenoldopam Follow-Up Studies Half-Life infection liposomes lung disease mice, inbred c57bl mice, knockout mortality rats risk factors surgery urine viral clearance administration, inhalation adolescent