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humans female male metabolism animals physiology genetics adult ireland middle aged pharmacology drug effects chemistry pathology aged psychology physiopathology diagnosis adolescent epidemiology time factors drug therapy etiology immunology microbiology therapeutic use risk factors blood mice therapy prevention & control complications young adult human signal transduction cytology child adverse effects pregnancy aged, 80 and over administration & dosage cell line statistics & numerical data biosynthesis questionnaires apoptosis surgery cattle cells, cultured education isolation & purification standards cell line, tumor antagonists & inhibitors gene expression treatment outcome rats prospective studies models, biological reproducibility of results instrumentation arts and humanities enzymology medicine and health sciences molecular sequence data classification growth & development gene expression regulation sensitivity and specificity organization & administration retrospective studies algorithms brain breast neoplasms rna, messenger