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humans animals female metabolism chemistry male physiology genetics ireland adult pharmacology drug effects middle aged cattle blood physics aged pathology microbiology epidemiology risk factors psychology isolation & purification diagnosis immunology time factors chromatography, high pressure liquid etiology adolescent mice electronic engineering physiopathology administration & dosage instrumentation pregnancy prevention & control drug therapy therapeutic use rats medicine and health sciences sensitivity and specificity high frequency adverse effects gene expression materials mechanical engineering cytology growth & development algorithms therapy reproducibility of results classification computer science enzymology molecular sequence data complications young adult biosynthesis education standards veterinary child statistics & numerical data irish this review aged, 80 and over questionnaires surgery analogs & derivatives cell line nanoscience & materials thin films water hydrogen-ion concentration