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humans metabolism animals physiology genetics male female chemistry drug effects pharmacology adult brain physiopathology pathology mice middle aged immunology rats aged ireland psychology cytology signal transduction blood etiology gene expression drug therapy diagnosis microbiology cell line biosynthesis this review enzymology medicine and health sciences molecular sequence data physics time factors therapeutic use adolescent complications cattle cells, cultured apoptosis antagonists & inhibitors protein binding density functional theory amino acid sequence therapy neuroscience human young adult mice, inbred c57bl algorithms models, biological proteins electronic engineering neurons disease models, animal nanoscience & materials administration & dosage gene expression regulation adverse effects rats, wistar risk factors computer science epidemiology schizophrenia cell line, tumor growth & development membrane proteins aged, 80 and over classification hippocampus instrumentation isolation & purification