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humans metabolism animals pharmacology drug effects genetics immunology physiology female male chemistry drug therapy pathology anti-bacterial agents therapeutic use microbiology mice adult inflammation biosynthesis middle aged apoptosis blood signal transduction antagonists & inhibitors physiopathology cytology aged administration & dosage cell line ireland prevention & control isolation & purification gene expression cells, cultured etiology therapy adverse effects cell line, tumor enzymology cytokines diagnosis microbial sensitivity tests cattle medicine and health sciences rats this review complications growth & development toll-like receptors immunology, inflammation & infection Tumor Necrosis Factor-alpha neutrophils epidemiology epithelial cells molecular sequence data adolescent gene expression regulation time factors cell proliferation cell survival enzyme-linked immunosorbent assay nf-kappa-b escherichia coli interleukin-6 interleukin-8 veterinary analogs & derivatives inflammatory bowel diseases dose-response relationship, drug inflammatory bowel disease immune response lipopolysaccharides immune system