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humans metabolism animals physiology pharmacology genetics drug effects chemistry female male ireland mice pathology adult immunology enzymology signal transduction cytology apoptosis biosynthesis cell line antagonists & inhibitors drug therapy rats physiopathology middle aged microbiology blood cattle cells, cultured psychology gene expression aged therapeutic use molecular sequence data cell line, tumor time factors education growth & development medicine and health sciences cell proliferation isolation & purification amino acid sequence protein binding phosphorylation administration & dosage physical activity analogs & derivatives gene expression regulation cell survival this review brain biochemistry prevention & control etiology models, biological adolescent cell cycle biotechnology kinetics epithelial cells transcription factors adverse effects blotting, western rna, messenger hydrogen-ion concentration rats, wistar bacterial proteins dose-response relationship, drug escherichia coli flow cytometry inflammation therapy recombinant proteins immunology, inflammation & infection