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humans animals metabolism chemistry female male physiology pharmacology drug effects genetics ireland adult cattle pathology middle aged blood rats mice aged cytology time factors administration & dosage immunology psychology apoptosis drug therapy microbiology antagonists & inhibitors physiopathology pregnancy biosynthesis enzymology analogs & derivatives isolation & purification veterinary signal transduction diagnosis adolescent cell line cells, cultured growth & development medicine and health sciences cell line, tumor epidemiology etiology therapeutic use adverse effects gene expression therapy physics risk factors prevention & control rats, wistar complications young adult molecular sequence data aged, 80 and over surgery water cell survival dose-response relationship, drug h+3 gene expression regulation prospective studies treatment outcome biotechnology child phosphorylation cell proliferation rna, messenger instrumentation h+2 mice, inbred c57bl caspase-3 kinetics