This inspection report sets out the findings of a monitoring inspection, the purpose of which was to inform a registration decision. This monitoring inspection was announced and took place over 2 day(s). The inspection took place over the following dates and times From: To: 11 May 2015 10:00 11 May 2015 17:30 12 May 2015 09:30 12 May 2015 16:00
This conference invites us to explore new organisational forms and practices that might be alternatives to 'neoliberal market managerialism' and 'financial capitalism'. Our starting point is that the latter two phenomena cannot be separated off analytically from powerful actors — such as the state — that have co-emerged with and played a key role in the evolutionary process through which capitalism has come to be (Graeber 2011). Specifically, this paper takes its move from Hobbes’s (1651/2005) idea of the Leviathan, which has provided a foundational intellectual basis for the nation-state form, which is today ubiquitous, and on which both neoliberalism and financial capitalism are reliant. Hobbes rooted his construct in a pessimistic view of humankind that is naturally inclined towards the 'war of all against all'. He argued that people must recognize that such a 'state of nature' is destructive, and must accept, on the basis of utilitarian reasoning, the necessity of a social contract to constitute a supreme actor whose power is absolute and enforced by a monopoly on violence. Hence, the Leviathan and the body politic are constituted at once and are irreversible. No exit is allowed; no ethical, moral or religious limit can be posed in front of this power. The Leviathan is total because there is no room for any other rationality, and finite because all people are tied to the social contract. Hobbes’s idea of the Leviathan has proved to be enduring and alluring, and provides a primary focus for this paper. What is especially interesting for us is that cryptocurrencies like Bitcoin have emerged from a similar 'thought experiment' beginning with a 'state of nature' not unlike Hobbes’s depiction. Here, the seminal contribution is by the mysterious individual or individuals known as Satoshi Nakamoto who, in 2008, published a paper that set out the basis for the 'blockchain technology' on which cryptocurrencies such as Bitcoin, and other services, are based (Nakamoto 2008). Not unlike Hobbes’s 'state of nature', Nakamoto begins with an imaginary world populated by trustless individuals. The problem he addresses is how to enable trustworthy transactions on the internet without recourse to a 'trusted third party', such as a state-regulated (and state-supported) bank. Indeed, in line with libertarian ideology, one of Nakamoto’s key objectives was to preclude the possibility of any single and all-encompassing ruling authority emerging. His elegant solution is Bitcoin, a purely digital cryptocurrency that is not administered by any constituted organization and is not circumscribed within any consistent jurisdiction. The 'blockchain', on which Bitcoin is based, is a public ledger of transactions maintained by a dispersed and open-ended number of 'miners' who provide computing power to maintain and guarantee the integrity of the ledger. While the Bitcoin economy is tiny compared to official currencies — but remarkable compared to alternative and local currencies — it plants the seeds of a currency (intended as a mode of regulating transactions) that could threaten many of the quasi-monopoly powers that the state currently exercises through the central bank, viz: surveying and collecting data on citizens and corporations, setting credit rates and monetary policy, deciding on and implementing exchange rate policies, assuring the robustness of the payment infrastructure, protecting the interests of consumers, controlling money-laundering, and regulating/supporting existing financial service providers (Murphy 2014). Nakamoto’s attempt to create a money system without a central authority is best seen at the intersection of diachronic and synchronic issues. Historically, the blockchain is one of a long string of information technologies that, since the 1960s, have avoided centralization, partly as a defence against possible Soviet nuclear attack, and partly in sympathy with the Western open culture of the 1960s and 1970s. In relation to contemporary phenomena, Bitcoin entangles with the state’s power and jurisdiction, which is simultaenously being challenged by the shadow economy, by individuals and corporations choosing where they wish to pay tax, by the free flow of information within trans-national information infrastructures, and by global internet services and commerce. While Hobbes and Nakamoto start from similar positions, they end up in quite different destinations, and, since theory can be performative (Austin 1970), this means that very different worlds come to be. Analytically, each provides a lens through which one can examine the other, in theory and in practice. Together, the lenses provide a framing device for reimagining key concepts and practices that underpin the contemporary nation-state and, by extension, financial capitalism. The full paper will report on this comparative analysis. The Bitcoin phenomenon raises interesting methodological and theoretical points that we will also explore in the paper. Methodologically, the actor-network injunction to 'follow the actors' — i.e. focus on performance — is practically impossible due to the sheer scale, technical intricacies, global dispersion and far-fetched effects of currency-related phenomena. Focusing on visible performance is also misleading theoretically because it fails to distinguish between what does not happen, those 'influences which operate behind the back of agents, and which therefore cannot be found in micro-situations' (Knorr-Cetina 1981: 28), and what is purposefully avoided (Law and Singleton 2005). Indeed, Bitcoin is a manifestation of a totem of digital cultures: there is always an elsewhere, beyond the control of organizations. Creating an elsewhere free from Leviathan’s constraints (which resonates with Foucault’s notion of heterotopia) disrupts the body politic by exceeding or overflowing its framings (Callon 1998). The peculiarity of Bitcoin is not in any frontal clash with authority but rather in its strategy of avoidance, which we might interpret as a form of différance or the playing of an alternative game. What Bitcoin also illustrates is that the link between the micro and the macro is neither based on an immutable social contract nor maintained by an unbounded power. Rather, scalable and publicly accessible computing resources coordinate trustless macro actions without necessarily constituting actors and identities (Czarniawska 2008/2014). The paper will further examine the paradox where the supplement of the age of visibility is action without actors and the emergence of new boundaries between frontstage and backstage, public and secret.
The International Conference held at Maynooth University in September, 2014, Creative Responses to Conflict through Mediation and Restorative Practice, brought together a diverse and outstanding gathering of scholars, practitioners and researchers who offered papers and workshops that represent the breadth and scope of the field of conflict intervention. The presenters described applications of techniques and strategies that reflect the field’s vitality, resourcefulness and imagination. In the winter issue of this Journal, the editors presented articles solicited from conference presenters, and in this second special issue, we present an additional seven pieces from authors, who presented workshops and papers.
This presentation addresses issues associated with the fines and settlements of over €100bn imposed on international banks by regulatory authorities in Europe and the USA in recent years. It examines the purpose of regulation and the background to the events and behaviours which resulted in transfers of this magnitude. It expresses some hypotheses regarding what may unfold in the future and gives weight to the examination of roles that exist in institutions party to these transfers. It suggests some tasks that may be helpful as the sector pursues the next phase in its journey, perhaps with certain redemptive attributes in mind.
Are women less corrupt in business? We revisit this question using firm-level data from the World Bank’s Enterprise Surveys, which measure firms’ experience of corruption and the gender of their owners and top managers. We find that women in positions of influence are associated with less corruption: female-owned businesses pay less in bribes and corruption is seen as less of an obstacle in companies where women are represented in top management. By providing evidence that women are, ethically at least, good for business our research contributes to the literature on development, gender equality, and corruption more generally.
During the euro crisis policy-makers tried to re-establish credibility with austere budgets. Studies of austerity have been plagued by measurement and endogeneity problems. We provide a direct test of the effect of austerity on confidence by calculating the immediate impact of austere budgets on government bonds. We build a unique database of budget dates and conduct event studies of 223 (future) Eurozone budgets. Since austere budgets are enacted in particular circumstances, we use a treatment effects design to measure markets’ responses. Our findings are discouraging for the argument that austerity can provide a positive credibility shock. Markets do not welcome austerity. On the contrary, austere budgets are associated with substantial interest rate increases. These results underline how constrained governments are in debt crises.
Azaspiracids (AZAs) are a group of biotoxins that cause food poisoning in humans. These toxins are produced by small marine dinoflagellates such as Azadinium spinosum and accumulate in shellfish. Ovine polyclonal antibodies were produced and used to develop an ELISA for quantitating AZAs in shellfish, algal cells, and culture supernatants. Immunizing antigens were prepared from synthetic fragments of the constant region of AZAs, while plate coating antigen was prepared from AZA-1. The ELISA provides a sensitive and rapid analytical method for screening large numbers of samples. It has a working range of 0.45-8.6 ng/mL and a limit of quantitation for total AZAs in whole shellfish at 57 μg/kg, well below the maximum permitted level set by the European Commission. The ELISA has good cross-reactivity to AZA-1-10, -33, and -34 and 37-epi-AZA-1. Naturally contaminated Irish mussels gave similar results whether they were cooked or uncooked, indicating that the ELISA also detects 22-carboxy-AZA metabolites (e.g., AZA-17 and AZA-19). ELISA results showed excellent correlation with LC-MS/MS analysis, both for mussel extract spiked with AZA-1 and for naturally contaminated Irish mussels. The assay is therefore well suited to screening for AZAs in shellfish samples intended for human consumption, as well as for studies on AZA metabolism.
The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the hormone, which go beyond the regulation of systemic energy metabolism. In this review, we discuss the diverse biological functions of ghrelin, the regulation of its secretion, and address questions that still remain 15 years after its discovery. In recent years, ghrelin has been found to have a plethora of central and peripheral actions in distinct areas including learning and memory, gut motility and gastric acid secretion, sleep/wake rhythm, reward seeking behavior, taste sensation and glucose metabolism.
The Cation Diffusion Facilitators (CDFs) form a family of membrane-bound proteins capable of transporting zinc and other heavy metal ions. Involved in metal tolerance/resistance by efflux of ions, CDF proteins share a two-modular architecture consisting of a transmembrane domain (TMD) and C-terminal domain (CTD) that protrudes into the cytoplasm. Discovery of a Zn(2+) and Cd(2+) CDF transporter from a marine bacterium Maricaulis maris that does not possess the CTD questions current perceptions regarding this family of proteins. This article describes a new, CTD-lacking subfamily of CDFs and our current knowledge about this family of proteins in the view of these findings.
A growing body of empirical research examines the effects of the so-called "social determinants of health" (SDH) on health and health inequalities. Several high-profile publications have issued policy recommendations to reduce health inequalities based on a specific interpretation of this empirical research as well as a set of normative assumptions. This article questions the framework defined by these assumptions by focusing on two issues: first, the normative judgments about the (un)fairness of particular health inequalities; and second, the policy recommendations issued on this basis. We argue that the normative underpinnings of the approach are insufficiently supported and that the policy recommendations do not necessarily follow from the arguments provided. Furthermore, while many of the policies recommended-such as improving people's living conditions and reducing inequalities in wealth and power-are justified in their own right, the way these recommendations are tied to health is problematic.
