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John F. Cryan

Institution

University College Cork

Contact

Subjects

Pharmacology

Details
Publications 200
As first author 6
As last author 113
Unique topics 931
Collaborations 117
Patents 1
Sources 12
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2015
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2013
2012
2011
2010
2009
2008
2007
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2015
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2013
2012
2011
2010
2009
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2007
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2015

Association Between Obstetric Mode of Delivery and Autism Spectrum Disorder: A Population-Based Sibling Design Study.
2015

Bovine serum albumin as the dominant form of dietary protein reduces subcutaneous fat mass, plasma leptin and plasma corticosterone in high fat-fed C57/BL6J mice.
2015

Cadaveric anatomy in the future of medical education: What is the surgeons view?
2015

Cyclodextrin mediated delivery of NF-κB and SRF siRNA reduces the invasion potential of prostate cancer cells in vitro.
2015

Dietary trans-10, cis-12-conjugated linoleic acid alters fatty acid metabolism and microbiota composition in mice.
2015

Enhancing glutamatergic transmission during adolescence reverses early-life stress-induced deficits in the rewarding effects of cocaine in rats.
2015

Ghrelin's Orexigenic Effect Is Modulated via a Serotonin 2C Receptor Interaction.
2015

Gut Microbiota: The Conductor in the Orchestra of Immune-Neuroendocrine Communication.
2015

Human preservation techniques in anatomy: A 21st century medical education perspective.
2015

Imaging of oxygen gradients in giant umbrella cells: an ex vivo PLIM study.
2015

Metabotropic Glutamate Receptors in Central Nervous System Diseases.
2015

Microbes & neurodevelopment - Absence of microbiota during early life increases activity-related transcriptional pathways in the amygdala.
2015

Microbiota regulation of the Mammalian gut-brain axis.
2015

Modulation of TLR3/TLR4 inflammatory signaling by the GABAB receptor agonist baclofen in glia and immune cells: relevance to therapeutic effects in multiple sclerosis.
2015

Prenatal stress-induced alterations in major physiological systems correlate with gut microbiota composition in adulthood.
2015

RNAi therapeutics for brain cancer: current advancements in RNAi delivery strategies.
2015

Serum BDNF as a peripheral biomarker of treatment-resistant depression and the rapid antidepressant response: A comparison of ketamine and ECT.
2015

The brain's Geppetto-microbes as puppeteers of neural function and behaviour?
2015

The impact of gut microbiota on brain and behaviour: implications for psychiatry.
2015

Thinking small: towards microRNA-based therapeutics for anxiety disorders.
2015

Treating disorders of the neonatal central nervous system: pharmacokinetic and pharmacodynamic considerations with a focus on anti-epileptics.
2015

When ageing meets the blues: Are current antidepressants effective in depressed aged patients?
2015

Whey protein isolate decreases murine stomach weight and intestinal length and alters the expression of Wnt signalling-associated genes
2015

n-3 PUFAs have beneficial effects on anxiety and cognition in female rats: Effects of early life stress.
2014

A prospective study of C-reactive protein as a state marker in Cardiac Syndrome X.
2014

A sustained hypothalamic-pituitary-adrenal axis response to acute psychosocial stress in irritable bowel syndrome.
2014

A ventral view on antidepressant action: roles for adult hippocampal neurogenesis along the dorsoventral axis.
2014

Acute tryptophan depletion reduces kynurenine levels: implications for treatment of impaired visuospatial memory performance in irritable bowel syndrome.
2014

Bacterial neuroactive compounds produced by psychobiotics.
2014

Bifidobacteria modulate cognitive processes in an anxious mouse strain.
2014

Collective unconscious: How gut microbes shape human behavior.
2014

Converging effects of a Bifidobacterium and Lactobacillus probiotic strain on mouse intestinal physiology.
2014

Delivering a disease-modifying treatment for Huntington's disease.
2014

Devil's Claw to suppress appetite--ghrelin receptor modulation potential of a Harpagophytum procumbens root extract.
2014

Disturbance of the gut microbiota in early-life selectively affects visceral pain in adulthood without impacting cognitive or anxiety-related behaviors in male rats.
2014

Downregulation of Umbilical Cord Blood Levels of miR-374a in Neonatal Hypoxic Ischemic Encephalopathy.
2014

Early-life stress induces persistent alterations in 5-HT1A receptor and serotonin transporter mRNA expression in the adult rat brain.
2014

Early-life stress selectively affects gastrointestinal but not behavioral responses in a genetic model of brain-gut axis dysfunction.
2014

Effect of acute swim stress on plasma corticosterone and brain monoamine levels in bidirectionally selected DxH recombinant inbred mouse strains differing in fear recall and extinction.
2014

Faster, better, stronger: Towards new antidepressant therapeutic strategies.
2014

Friends with social benefits: host-microbe interactions as a driver of brain evolution and development?
2014

GABAB receptors as a therapeutic strategy in substance use disorders: focus on positive allosteric modulators.
2014

GABAB(1) receptor subunit isoforms differentially regulate stress resilience.
2014

Genomics of schizophrenia: time to consider the gut microbiome?
2014

Gut microbes and the brain: paradigm shift in neuroscience.
2014

Gut microbiota depletion from early adolescence in mice: Implications for brain and behaviour.
2014

Gut microbiota, the pharmabiotics they produce and host health.
2014

Irritable bowel syndrome: a microbiome-gut-brain axis disorder?
2014

Medical student knowledge regarding radiology before and after a radiological anatomy module: implications for vertical integration and self-directed learning.
2014

Medical student perceptions of radiology use in anatomy teaching.
2014

Microbiota and neurodevelopmental windows: implications for brain disorders.
2014

Minireview: Gut microbiota: the neglected endocrine organ.
2014

Nanoparticles and the blood-brain barrier: advancing from in-vitro models towards therapeutic significance.
2014

PEGylated cyclodextrins as novel siRNA nanosystems: correlations between polyethylene glycol length and nanoparticle stability.
2014

Priming for health: gut microbiota acquired in early life regulates physiology, brain and behaviour.
2014

Protein Quality and the Protein to Carbohydrate Ratio within a High Fat Diet Influences Energy Balance and the Gut Microbiota In C57BL/6J Mice
2014

Research Review: Birth by caesarean section and development of autism spectrum disorder and attention-deficit/hyperactivity disorder: a systematic review and meta-analysis.
2014

Serotonin, tryptophan metabolism and the brain-gut-microbiome axis.
2014

Soluble mediators in plasma from irritable bowel syndrome patients excite rat submucosal neurons.
2014

Streptozotocin-induced type-1-diabetes disease onset in Sprague-Dawley rats is associated with an altered intestinal microbiota composition and decreased diversity.
2014

Stress-induced visceral pain: toward animal models of irritable-bowel syndrome and associated comorbidities.
2014

Synthesis and characterization of rabies virus glycoprotein-tagged amphiphilic cyclodextrins for siRNA delivery in human glioblastoma cells: In vitro analysis.
2014

The effect of organic anion transporter 3 inhibitor probenecid on bumetanide levels in the brain: an integrated in vivo microdialysis study in the rat.
2014

The impact of microbiota on brain and behavior: mechanisms & therapeutic potential.
2014

The impact of obstetric mode of delivery on childhood behavior.
2014

The mouse cyclophosphamide model of bladder pain syndrome: tissue characterization, immune profiling, and relationship to metabotropic glutamate receptors.
2013

A review of ketamine in affective disorders: current evidence of clinical efficacy, limitations of use and pre-clinical evidence on proposed mechanisms of action.
2013

Activation but not blockade of GABAB receptors during early-life alters anxiety in adulthood in BALB/c mice.
2013

Adult siRNA-induced knockdown of mGlu7 receptors reduces anxiety in the mouse.
2013

Antipsychotics and the gut microbiome: olanzapine-induced metabolic dysfunction is attenuated by antibiotic administration in the rat.
2013

Bifidobacteria exert strain-specific effects on stress-related behavior and physiology in BALB/c mice.
2013

Biological and psychological markers of stress in humans: focus on the Trier Social Stress Test.
2013

Cationic and PEGylated Amphiphilic Cyclodextrins: Co-Formulation Opportunities for Neuronal Sirna Delivery.
2013

Cognitive performance in irritable bowel syndrome: evidence of a stress-related impairment in visuospatial memory.
2013

Cyclodextrins for non-viral gene and siRNA delivery
2013

Differential activation of the prefrontal cortex and amygdala following psychological stress and colorectal distension in the maternally separated rat.
2013

Differential nanotoxicological and neuroinflammatory liabilities of non-viral vectors for RNA interference in the central nervous system.
2013

Differential visceral nociceptive, behavioural and neurochemical responses to an immune challenge in the stress-sensitive Wistar Kyoto rat strain.
2013

Differential visceral pain sensitivity and colonic morphology in four common laboratory rat strains.
2013

Disodium cromoglycate reverses colonic visceral hypersensitivity and influences colonic ion transport in a stress-sensitive rat strain.
2013

Drugs, genes and the blues: pharmacogenetics of the antidepressant response from mouse to man.
2013

GABAB receptor ligands do not modify conditioned fear responses in BALB/c mice.
2013

Ghrelin at the interface of obesity and reward.
2013

Human P-glycoprotein differentially affects antidepressant drug transport: relevance to blood-brain barrier permeability.
2013

Long-lasting glutamatergic modulation induced by neonatal GABA enhancement in mice.
2013

Melancholic microbes: a link between gut microbiota and depression?
2013

Milk protein hydrolysates activate 5-HT(2C) serotonin receptors: influence of the starting substrate and isolation of bioactive fractions.
2013

Non-Viral Nanosystems for Gene and Small Interfering RNA Delivery to the Central Nervous System: Formulating the Solution.
2013

P-glycoprotein Inhibition Increases the Brain Distribution and Antidepressant-Like Activity of Escitalopram in Rodents.
2013

Protein quality and the protein to carbohydrate ratio within a high fat diet influences energy balance and the gut microbiota in C57BL/6J mice.
2013

Psychobiotics: A Novel Class of Psychotropic.
2013

Selective influence of host microbiota on cAMP-mediated ion transport in mouse colon.
2013

Strain differences in stress-induced changes in central CRF1 receptor expression.
2013

Taking two to tango: a role for ghrelin receptor heterodimerization in stress and reward.
2013

The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram.
2013

The effects of mGlu7 receptor modulation in behavioural models sensitive to antidepressant action in two mouse strains.
2013

The microbiome: stress, health and disease.
2013

Toll-like receptor 4 regulates chronic stress-induced visceral pain in mice.
2013

Towards translational rodent models of depression.
2013

Whey protein isolate counteracts the effects of a high-fat diet on energy intake and hypothalamic and adipose tissue expression of energy balance-related genes.
2013

microRNAs as novel antidepressant targets: converging effects of ketamine and electroconvulsive shock therapy in the rat hippocampus.
2012

A Distinct Profile of Tryptophan Metabolism along the Kynurenine Pathway Downstream of Toll-Like Receptor Activation in Irritable Bowel Syndrome.
2012

A click chemistry route to 2-functionalised PEGylated and cationic beta-cyclodextrins: co-formulation opportunities for siRNA delivery
2012

A click chemistry route to 2-functionalised PEGylated and cationic β-cyclodextrins: co-formulation opportunities for siRNA delivery.
2012

Alterations in prefrontal cortical serotonin and antidepressant-like behavior in a novel C3H/HeJxDBA/2J recombinant inbred mouse strain.
2012

Bifidobacterium breve with α-Linolenic Acid and Linoleic Acid Alters Fatty Acid Metabolism in the Maternal Separation Model of Irritable Bowel Syndrome
2012

Characterisation of cationic amphiphilic cyclodextrins for neuronal delivery of siRNA: effect of reversing primary and secondary face modifications
2012

Click-modified cyclodextrins as non-viral vectors for neuronal siRNA delivery
2012

Crosstalk between interleukin-6 and corticotropin-releasing factor modulate submucosal plexus activity and colonic secretion.
2012

Differential lipopolysaccharide-induced immune alterations in the hippocampus of two mouse strains: effects of stress.
2012

Dynamic 5-HT2C receptor editing in a mouse model ofobesity
2012

Ghrelin signalling and obesity: at the interface of stress, mood and food reward.
2012

Hippocampal group III mGlu receptor mRNA levels are not altered in specific mouse models of stress, depression and antidepressant action.
2012

Impact of early-life stress, on group III mGlu receptor levels in the rat hippocampus: Effects of ketamine, electroconvulsive shock therapy and fluoxetine treatment.
2012

In Vitro Investigations of the Efficacy of Cyclodextrin-siRNA Complexes Modified with Lipid-PEG-Octaarginine: Towards a Formulation Strategy for Non-viral Neuronal siRNA Delivery.
2012

In vitro investigations of the efficacy of cyclodextrin-siRNA complexes modified with lipid-PEG-octaarginine: towards a formulation strategy for effective neuronal siRNA delivery
2012

Inhibition of P-glycoprotein enhances transport of imipramine across the blood-brain barrier: microdialysis studies in conscious freely moving rats.
2012

Interleukin-6 modulates colonic transepithelial ion transport in the stress-sensitive wistar kyoto rat.
2012

Lithium augmentation of the effects of desipramine in a mouse model of treatment-resistant depression: a role for hippocampal cell proliferation.
2012

Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour.
2012

Phenotypic effects of repeated psychosocial stress during adolescence in mice mutant for the schizophrenia risk gene neuregulin-1: a putative model of gene × environment interaction.
2012

Promiscuous dimerization of the growth hormone secretagogue receptor (GHS-R1a) attenuates ghrelin-mediated signaling.
2012

Regulation of the stress response by the gut microbiota: implications for psychoneuroendocrinology.
2012

Rodent models of colorectal distension.
2012

Schizophrenia patients with a history of childhood trauma have a pro-inflammatory phenotype
2012

Self-assembling Modified β-Cyclodextrin Nanoparticles as Neuronal siRNA Delivery Vectors: Focus on Huntington's Disease.
2012

Semagacestat, a γ-secretase inhibitor, activates the growth hormone secretagogue (GHS-R1a) receptor.
2012

The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner.
2011

Altered expression and secretion of colonic interleukin-6 in a stress-sensitive animal model of brain-gut axis dysfunction.
2011

Altered peripheral toll-like receptor responses in the irritable bowel syndrome.
2011

An effective dietary method for chronic tryptophan depletion in two mouse strains illuminates a role for 5-HT in nesting behaviour.
2011

BDNF expression in the hippocampus of maternally separated rats: does Bifidobacterium breve 6330 alter BDNF levels?
2011

Behavioral satiety sequence in a genetic mouse model of obesity: effects of ghrelin receptor ligands.
2011

Blockade of the GABA(B) receptor increases neurogenesis in the ventral but not dorsal adult hippocampus: relevance to antidepressant action.
2011

Brain-gut-microbe communication in health and disease.
2011

Chronic psychosocial stress induces visceral hyperalgesia in mice.
2011

Chronic stress-induced alterations in mouse colonic 5-HT and defecation responses are strain dependent.
2011

Diet-induced obesity blunts the behavioural effects of ghrelin: studies in a mouse-progressive ratio task.
2011

Do interactions between stress and immune responses lead to symptom exacerbations in irritable bowel syndrome?
2011

Dynamic 5-HT2C receptor editing in a mouse model of obesity.
2011

Early-life stress induces visceral hypersensitivity in mice.
2011

Enhanced peripheral toll-like receptor responses in psychosis: further evidence of a pro-inflammatory phenotype.
2011

Exciting times beyond the brain: metabotropic glutamate receptors in peripheral and non-neural tissues.
2011

Gender-dependent consequences of chronic olanzapine in the rat: effects on body weight, inflammatory, metabolic and microbiota parameters.
2011

Genetic vs. pharmacological inactivation of COMT influences cannabinoid-induced expression of schizophrenia-related phenotypes.
2011

Gut memories: towards a cognitive neurobiology of irritable bowel syndrome.
2011

High-fat diet selectively protects against the effects of chronic social stress in the mouse.
2011

Increased sensitivity to the effects of chronic social defeat stress in an innately anxious mouse strain.
2011

Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
2011

Interactions between antidepressants and P-glycoprotein at the blood-brain barrier: clinical significance of in vitro and in vivo findings.
2011

Lithium-induced effects on adult hippocampal neurogenesis are topographically segregated along the dorso-ventral axis of stressed mice.
2011

Little things on which happiness depends: microRNAs as novel therapeutic targets for the treatment of anxiety and depression.
2011

Menstrual cycle influences Toll-like receptor responses.
2011

Review article: probiotics for the treatment of irritable bowel syndrome--focus on lactic acid bacteria.
2011

The age of anxiety: role of animal models of anxiolytic action in drug discovery.
2011

The microbiome-gut-brain axis: from bowel to behavior.
2011

The temporal impact of chronic intermittent psychosocial stress on high-fat diet-induced alterations in body weight.
2010

A Gut Feeling about GABA: Focus on GABA(B) Receptors.
2010

A novel role for the metabotropic glutamate receptor-7: modulation of faecal water content and colonic electrolyte transport in the mouse.
2010

Alterations in the central CRF system of two different rat models of comorbid depression and functional gastrointestinal disorders.
2010

Colonic soluble mediators from the maternal separation model of irritable bowel syndrome activate submucosal neurons via an interleukin-6-dependent mechanism.
2010

Comparison of hippocampal metabotropic glutamate receptor 7 (mGlu7) mRNA levels in two animal models of depression.
2010

Differential stress-induced alterations in tryptophan hydroxylase activity and serotonin turnover in two inbred mouse strains.
2010

Distinct alterations in colonic morphology and physiology in two rat models of enhanced stress-induced anxiety and depression-like behaviour.
2010

Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression.
2010

GABAB receptors and depression. Current status.
2010

IBS: An epigenetic perspective.
2010

Is there altered sensitivity to ghrelin-receptor ligands in leptin-deficient mice?: importance of satiety state and time of day.
2010

Maternal separation as a model of brain-gut axis dysfunction.
2010

Neonatal maternal separation in the rat impacts on the stress responsivity of central corticotropin-releasing factor receptors in adulthood.
2010

Progressive ratio responding in an obese mouse model: Effects of fenfluramine.
2010

Resistance to early-life stress in mice: effects of genetic background and stress duration.
2010

Restraint stress-induced brain activation patterns in two strains of mice differing in their anxiety behaviour.
2010

Strain differences in the neurochemical response to chronic restraint stress in the rat: relevance to depression.
2010

The effects of gabapentin in two animal models of co-morbid anxiety and visceral hypersensitivity.
2010

The effects of repeated social interaction stress on behavioural and physiological parameters in a stress-sensitive mouse strain.
2010

The probiotic Bifidobacterium infantis 35624 displays visceral antinociceptive effects in the rat.
2010

Therapeutic targeting in the silent era: advances in non-viral siRNA delivery
2009

5-HT(2B) receptors modulate visceral hypersensitivity in a stress-sensitive animal model of brain-gut axis dysfunction.
2009

Alterations in colonic corticotropin-releasing factor receptors in the maternally separated rat model of irritable bowel syndrome: differential effects of acute psychological and physical stressors.
2009

Chain reactions: early-life stress alters the metabolic profile of plasma polyunsaturated fatty acids in adulthood.
2009

Colorectal distension-induced prefrontal cortex activation in the Wistar-Kyoto rat: implications for irritable bowel syndrome.
2009

Differential stress-induced alterations of colonic corticotropin-releasing factor receptors in the Wistar Kyoto rat.
2009

Irritable bowel syndrome: towards biomarker identification.
2009

Lean mean fat reducing "ghrelin" machine: hypothalamic ghrelin and ghrelin receptors as therapeutic targets in obesity.
2009

Leptin-deficient mice retain normal appetitive spatial learning yet exhibit marked increases in anxiety-related behaviours.
2009

Marked elevations in pro-inflammatory polyunsaturated fatty acid metabolites in females with irritable bowel syndrome.
2009

Metabotropic glutamate receptor 7: at the interface of cognition and emotion.
2009

Riluzole normalizes early-life stress-induced visceral hypersensitivity in rats: role of spinal glutamate reuptake mechanisms.
2009

Toll-like receptor mRNA expression is selectively increased in the colonic mucosa of two animal models relevant to irritable bowel syndrome
2009

Tryptophan degradation in irritable bowel syndrome: evidence of indoleamine 2,3-dioxygenase activation in a male cohort
2009

Verapamil in treatment resistant depression: a role for the P-glycoprotein transporter?
2008

"Killing the Blues": a role for cellular suicide (apoptosis) in depression and the antidepressant response?
2008

Enhanced cholinergic-mediated increase in the pro-inflammatory cytokine IL-6 in irritable bowel syndrome: role of muscarinic receptors.
2008

Region specific decrease in glial fibrillary acidic protein immunoreactivity in the brain of a rat model of depression.
2008

Tryptophan catabolism in females with irritable bowel syndrome: relationship to interferon-gamma, severity of symptoms and psychiatric co-morbidity.
2008

Tryptophan degradation in irritable bowel syndrome: evidence of indoleamine 2,3-dioxygenase activation in a male cohort.
2007

Emerging use of non-viral RNA interference in the brain.
2006

Animal models of mood disorders: Recent developments.
2006

Concomitant deficits in working memory and fearextinction are functionally dissociated from reduced anxiety in metabotropic glutamate receptor 7-deficient mice

These are the 12 unique sources for John F. Cryan's 200 publications. A single publication may appear in multiple sources. Click on a name or publication count to see the publications for a particular source.

Source #
Ireland -> Dublin City University 1
Ireland -> Dublin City University -> PubMed 1
Ireland -> Royal College of Surgeons in Ireland 2
Ireland -> Royal College of Surgeons in Ireland -> PubMed 2
Ireland -> Teagasc 17
Ireland -> Teagasc -> PubMed 14
Ireland -> Trinity College Dublin 3
Ireland -> Trinity College Dublin -> PubMed 3
Ireland -> University College Cork 176
Ireland -> University College Cork -> PubMed 165
Ireland -> University of Limerick 1
Ireland -> University of Limerick -> PubMed 1
25-Jul-2013

GABA-PRODUCING CULTURABLE BACTERIA DERIVED FROM THE HUMAN GASTROINTESTINAL TRACT
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