Experts
 Menu

Luke Anthony John O'Neill

Institution

Trinity College Dublin

Contact

Subjects

Biochemistry

Microbiology

Details
Publications 185
As first author 80
As last author 122
Unique topics 836
Collaborations 108
Patents 4
Sources 12
Are you Luke Anthony John O'Neill? Click here to provide feedback on your profile.
All
2015
2014
2013
2012
2011
2010
2009
2008
2007
Earlier
All
2015
2014
2013
2012
2011
2010
2009
2008
2007
Earlier

2015

A broken krebs cycle in macrophages.
2015

Circadian control of innate immunity in macrophages by miR-155 targeting Bmal1
2015

Glutathione transferase Omega 1 modulates metabolism in LPS/TLR4 activated macrophages.
2015

Metabolic reprogramming in macrophages and dendritic cells in innate immunity.
2015

Metformin Inhibits the Production of Reactive Oxygen Species from NADH:Ubiquinone Oxidoreductase to Limit Induction of Interleukin-1β (IL-1β) and Boosts Interleukin-10 (IL-10) in Lipopolysaccharide (LPS)-activated Macrophages.
2015

Monounsaturated Fatty Acid-Enriched High-Fat Diets Impede Adipose NLRP3 Inflammasome-Mediated IL-1β Secretion and Insulin Resistance Despite Obesity.
2015

NLRP3 at the interface of metabolism and inflammation.
2015

Protective Role for Caspase-11 during Acute Experimental Murine Colitis.
2015

Pyruvate Kinase M2 Regulates Hif-1alfa Activity and IL-1ß Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages.
2015

The Cellular and Molecular Basis of Translational Immunometabolism.
2014

A critical role for the TLR signaling adapter Mal in alveolar macrophage-mediated protection against Bordetella pertussis.
2014

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.
2014

Circadian Clock Proteins and Immunity
2014

Glutathione transferase omega 1 is required for the lipopolysaccharide-stimulated induction of NADPH oxidase 1 and the production of reactive oxygen species in macrophages.
2014

LPS induces the degradation of programmed cell death protein 4 (PDCD4) to release Twist2, activating c-Maf transcription to promote interleukin-10 production.
2014

Metabolic reprograming in macrophage polarization.
2014

MyD88 adaptor-like (Mal) regulates intestinal homeostasis and colitis-associated colorectal cancer in mice.
2014

Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation.
2014

Protective role for caspase-11 during acute experimental murine colitis.
2014

Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages.
2014

TRIL is involved in cytokine production in the brain following Escherichia coli infection.
2014

Targeting T cell immunometabolism for cancer immunotherapy; understanding the impact of the tumor microenvironment.
2014

The MyD88+ Phenotype Is an Adverse Prognostic Factor in Epithelial Ovarian Cancer.
2014

The role of Ets2 transcription factor in the induction of microRNA-155 by LPS, and its targeting by IL-10.
2014

mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity.
2013

A long noncoding RNA mediates both activation and repression of immune response genes.
2013

Bruton's Tyrosine Kinase Mediates the Synergistic Signalling between TLR9 and the B Cell Receptor by Regulating Calcium and Calmodulin
2013

Building unique bonds to fight misplaced DNA
2013

Cardiolipin and the Nlrp3 inflammasome.
2013

Conjugated linoleic acid suppresses IRF3 activation via modulation of CD14.
2013

Distinct Mechanisms for Induction and Tolerance Regulate the Immediate Early Genes Encoding Interleukin 1β and Tumor Necrosis Factor α
2013

How metabolism generates signals during innate immunity and inflammation
2013

Metabolism of inflammation limited by AMPK and pseudo-starvation.
2013

Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments.
2013

MyD88 adaptor-like (Mal) functions in the epithelial barrier and contributes to intestinal integrity via protein kinase C.
2013

NFκB2 p52 has a role in antiviral immunity through IKK{epsilon}-dependent induction of Sp1 and IL-15.
2013

NLRP3 and IL-1β in macrophages as critical regulators of metabolic diseases.
2013

Nuclear factor κB2 p52 protein has a role in antiviral immunity through IκB kinase epsilon-dependent induction of Sp1 protein and interleukin 15.
2013

Succinate is an inflammatory signal that induces IL-1 beta through HIF-1 alpha
2013

Succinate: a metabolic signal in inflammation
2013

The GOLD Domain-containing Protein TMED1 Is Involved in Interleukin-33 Signaling.
2013

The GOLD domain-containing protein TMED1 is involved in IL-33 signalling.
2013

The Role of Ets2 Transcription Factor in the Induction of MicroRNA-155 (miR-155) by Lipopolysaccharide and Its Targeting by Interleukin-10.
2013

The Warburg effect then and now: From cancer to inflammatory diseases
2013

The history of Toll-like receptors-redefining innate immunity
2013

The impact of childhood obesity on inflammation, innate immune cell frequency, and metabolic microRNA expression.
2013

miR-223: Infection, inflammation and cancer
2012

"Transflammation": when innate immunity meets induced pluripotency.
2012

Biochemical regulation of the inflammasome.
2012

Both TLR2 and TRIF contribute to interferon-? production during Listeria infection.
2012

Cutting edge: miR-223 and EBV miR-BART15 regulate the NLRP3 inflammasome and IL-1β production.
2012

Metabolism of inflammation limited by AMPK and pseudo-starvation.
2012

Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments.
2012

New developments in Toll-like receptor targeted therapeutics.
2012

Succinate is an inflammatory signal that induces IL-1β through HIF-1α.
2012

miR-107: a toll-like receptor-regulated miRNA dysregulated in obesity and type II diabetes.
2011

A Role for TLR4 in Clostridium difficile Infection and the Recognition of Surface Layer Proteins
2011

A critical role for citrate metabolism in LPS signalling.
2011

A trio of microRNAs that control Toll-like receptor signalling.
2011

Blockade of Toll-like receptor 2 prevents spontaneous cytokine release from rheumatoid arthritis ex vivo synovial explant cultures.
2011

Conjugated linoleic acid suppresses IRF3 activation via modulation of CD14.
2011

Counter-regulation in the IKK family.
2011

Mal mediates TLR-induced activation of CREB and expression of IL-10.
2011

MicroRNAs and the resolution phase of in?ammation in macrophages
2011

MicroRNAs and the resolution phase of inflammation in macrophages.
2011

MicroRNAs: the fine-tuners of Toll-like receptor signalling.
2011

Mycobacterial PIMs Inhibit Host Inflammatory Responses through CD14-Dependent and CD14-Independent Mechanisms
2011

NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components.
2011

The Cytokine Release Inhibitory Drug CRID3 Targets ASC Oligomerisation in the NLRP3 and AIM2 Inflammasomes
2011

The GOLD domain-containing protein TMED7 inhibits TLR4 signalling from the endosome upon LPS stimulation.
2011

The emerging role of metabolic regulation in the functioning of Toll-like receptors and the NOD-like receptor Nlrp3
2011

The inflammasome in atherosclerosis and type 2 diabetes.
2011

The powerstroke and camshaft of the RIG-I antiviral RNA detection machine.
2011

Toll-like receptor (TLR) 3 signaling requires the TLR4 interactor with leucine-rich repeats (TRIL).
2011

Toll-like receptor 3 (TLR3) signaling requires TLR4 Interactor with leucine-rich REPeats (TRIL).
2011

Toll-like receptor 4 (TLR4) down-regulates microRNA-107 increasing macrophage adhesion via cyclin-dependent kinase 6
2011

Tribbles 3: a novel regulator of TLR2-mediated signaling in response to Helicobacter pylori lipopolysaccharide.
2010

A role for TLR4 in Clostridium difficile infection and the recognition of surface layer proteins.
2010

Detecting microRNA activity from gene expression data.
2010

Disease-associated amyloid and misfolded protein aggregates activate the inflammasome.
2010

IL-10 inhibits miR-155 induction by Toll-like receptors.
2010

IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal).
2010

Myocardial ischemia/reperfusion injury is mediated by leukocytic toll-like receptor-2 and reduced by systemic administration of a novel anti-toll-like receptor-2 antibody.
2010

New insights into the regulation of signalling by toll-like receptors and nod-like receptors.
2010

Regulators of TLR4 signaling by endotoxins.
2010

Sensing and Signaling in Antiviral Innate Immunity
2010

TILRR, a novel IL-1RI co-receptor, potentiates MyD88 recruitment to control ras-dependent amplification of NF-?B
2010

Targeting Toll-like receptors: emerging therapeutics?
2009

Boosting the brain's ability to block inflammation via microRNA-132.
2009

DNA makes RNA makes innate immunity.
2009

Detecting microRNA activity from gene expression data.
2009

Listeria monocytogenes infection in the face of innate immunity.
2009

Localisation and trafficking of Toll-like receptors: an important mode of regulation.
2009

MyD88 adaptor-like is not essential for TLR2 signaling and inhibits signaling by TLR3.
2009

Rab39a binds caspase-1 and is required for caspase-1-dependent il-1{beta} secretion
2009

Recent insights into the structure of Toll-like receptors and post-translational modifications of their associated signalling proteins.
2009

TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain.
2009

The role of TLRs, NLRs, and RLRs in mucosal innate immunity and homeostasis.
2009

Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer.
2009

Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome.
2008

Adding fuel to fire: microRNAs as a new class of mediators of inflammation.
2008

Genetic variation in Toll-like receptor signalling and the risk of inflammatory and immune diseases.
2008

Glucocorticoids inhibit IRF3 phosphorylation in response to Toll-like
2008

Glucocorticoids inhibit IRF3 phosphorylation in response to Toll-like receptor-3 and -4 by targeting TBK1 activation.
2008

Innate immunity: squelching anti-viral signalling with NLRX1.
2008

TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway.
2008

The Mal/TIRAP S180L and TLR4 G299D polymorphisms are not associated with susceptibility to, or severity of, rheumatoid arthritis.
2008

The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress.
2008

Tyrosine phosphorylation of MyD88 adapter-like (Mal) is critical for signal transduction and blocked in endotoxin tolerance
2008

When signaling pathways collide: positive and negative regulation of toll-like receptor signal transduction.
2007

A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins.
2007

A functional variant in MAL/TIRAP and protection against invasive pneumococcal disease, bacteraemia, malaria and tuberculosis
2007

Camelpox virus encodes a schlafen-like protein that affects orthopoxvirus
2007

Diversity and regulation in the NF-kappaB system.
2007

How important are Toll-like receptors for antimicrobial responses?
2007

Inflammasomes in inflammatory disorders: the role of TLRs and their interactions with NLRs.
2007

Mass Spectrometric Analysis of the Endogenous Type I Interleukin-1 (IL-1) Receptor Signaling Complex Formed after IL-1 Binding Identifies IL-1RAcP, MyD88, and IRAK-4 as the Stable Components
2007

NF-kappaB activation by the Toll-IL-1 receptor domain-containing protein Mal is regulated by caspase-1
2007

Primer: Toll-like receptor signaling pathways--what do rheumatologists need to know?
2007

Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase.
2007

Signalling of toll-like receptors.
2007

The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling
2007

The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling.
2007

The role of toll-like receptors in macrophages.
2007

Toll-like receptors: key activators of leucocytes and regulator of haematopoiesis.
2006

IkappaB kinase epsilon interacts with p52 and promotes transactivation via p65
2006

MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction
2006

New insights into the regulation of TLR signaling
2006

Resolution of inflammation: state of the art, definitions and terms
2006

The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction
2006

Toll-like receptors: from the discovery of NFkappaB to new insights into transcriptional regulations in innate immunity.
2006

Trif-related adapter molecule is phosphorylated by PKC{epsilon} during Toll-like receptor 4 signaling.
2006

Trif-related adapter molecule is phosphorylated by protein kinase C epsilon during Toll-like receptor 4 signalling
2005

Adaptor usage and Toll-like receptor signaling specificity.
2005

Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NF-kappa B activation by LPS
2005

How Toll-like receptors signal: what we know and what we don't know.
2005

New insights into the post-translational modification of Toll-like receptor signaling molecules.
2005

Schlafen-1 causes a cell cycle arrest by inhibiting induction of cyclin D1
2005

Schlafen-1 causes a cell cycle arrest by inhibiting induction of cyclin D1.
2004

Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL
2004

Human tribbles, a protein family controlling mitogen-activated protein kinase cascades
2004

Mal interacts with tumor necrosis factor receptor-associated factor (TRAF)-6 to mediate NF-kappaB activation by toll-like receptor (TLR)-2 and TLR4
2004

Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4
2004

The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction.
2004

The murine IRAK2 gene encodes four alternatively spliced isoforms, two of which are inhibitory
2004

Transcriptional regulation of the human TRIF (TIR domain-containing adaptor protein inducing interferon beta) gene.
2003

Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4
2003

Interferon regulatory factor-3-mediated activation of the interferon-sensitive response element by Toll-like receptor (TLR) 4 but not TLR3 requires the p65 subunit of NF-kappa
2003

Mal and MyD88: adapter proteins involved in signal transduction by Toll-like receptors.
2003

Structural complementarity of Toll/interleukin-1 receptor domains in Toll-like receptors and the adaptors Mal and MyD88
2003

The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defence
2003

The role of MyD88-like adapters in Toll-like receptor signal transduction.
2003

Therapeutic targeting of Toll-like receptors for inflammatory and infectious diseases.
2002

Characterization of signaling pathways activated by the interleukin 1 (IL-1) receptor homologue T1/ST2. A role for Jun N-terminal kinase in IL-4 induction
2002

Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1
2002

Signal transduction pathways activated by the IL-1 receptor/toll-like receptor superfamily.
2001

Internalin B activates nuclear factor-kappa B via Ras, phosphoinositide 3-kinase, and Akt
2001

The anti-inflammatory cytokine, interleukin (IL)-10, blocks the inhibatory effect of IL-1 beta on long term potentiation - a role for JNK
2001

The serine protease inhibitor antithrombin III inhibits LPS-mediated NF-kappaB activation by TLR-4.
2001

Transactivation by the p65 subunit of NF-kappaB in response to interleukin-1 (IL-1) involves MyD88, IL-1 receptor-associated kinase 1, TRAF-6, and Rac1
2000

A method to predict residues conferring functional differences between related proteins: application to MAP kinase pathways
2000

A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling
2000

Divergent roles for Ras and Rap in the activation of p38 mitogen-activated protein kinase by interleukin-1
2000

Modulation of innate and acquired immune responses by Escherichia coli heat-labile toxin: distinct pro- and anti-inflammatory effects of the nontoxic AB complex and the enzyme activity
2000

Rac1 regulates interleukin 1-induced nuclear factor kappaB activation in an inhibitory protein kappaBalpha-independent manner by enhancing the ability of the p65 subunit to transactivate gene expression
2000

The Toll/interleukin-1 receptor domain: a molecular switch for inflammation and host defence.
2000

The interleukin-1 receptor/Toll-like receptor superfamily: signal generators for pro-inflammatory interleukins and microbial products
2000

Topoisomerase II is required for mitoxantrone to signal nuclear factor kappa B activation in HL60 cells
2000

Vitamin C inhibits NF-kappa B activation by TNF via the activation of p38 mitogen-activated protein kinase
1999

Characterization of CD44 induction by IL-1: a critical role for Egr-1
1999

The evolution of the MAP kinase pathways: coduplication of interacting proteins leads to new signaling cascades.
1998

Ceramide activates NFkappaB by inducing the processing of p105
1998

Signal transduction pathways activated by the IL-1 receptor family: ancient signaling machinery in mammals, insects, and plants.
1997

2-mercaptoethanol restores the ability of nuclear factor kappa B (NF kappa B) to bind DNA in nuclear extracts from interleukin 1-treated cells incubated with pyrollidine dithiocarbamate (PDTC)
1997

Daunorubicin activates NFkappaB and induces kappaB-dependent gene expression in HL-60 promyelocytic and Jurkat T lymphoma cells
1997

NF-kappa B: a crucial transcription factor for glial and neuronal cell function.
1997

Staurosporine, but not Ro 31-8220, induces interleukin 2 production and synergizes with interleukin 1alpha in EL4 thymoma cells.
1995

Cellular proliferation and activation of NF kappa B are induced by autocrine production of tumor necrosis factor alpha in the human T lymphoma line HuT 78
1995

Signalling via CD28 of human naive neonatal T lymphocytes.
1995

Studies into the effect of the tyrosine kinase inhibitor herbimycin A on NF-kappa B activation in T lymphocytes. Evidence for covalent modification of the p50 subunit.
1993

Interleukin-1 activates transcription factor NF kappa B in glial cells
1992

Interleukin 1 induces NF-kappa B through its type I but not its type II receptor in lymphocytes.
1990

Interleukin-1 signal transduction: increased GTP binding and hydrolysis in membranes of a murine thymoma line (EL4).
1987

Extracts of feverfew inhibit mitogen-induced human peripheral blood mononuclear cell proliferation and cytokine mediated responses: a cytotoxic effect

These are the 12 unique sources for Luke Anthony John O'Neill's 184 publications. A single publication may appear in multiple sources. Click on a name or publication count to see the publications for a particular source.

Source #
Ireland -> Dublin City University 2
Ireland -> Dublin City University -> PubMed 2
Ireland -> Maynooth University 2
Ireland -> Maynooth University -> PubMed 1
Ireland -> Royal College of Surgeons in Ireland 3
Ireland -> Royal College of Surgeons in Ireland -> PubMed 3
Ireland -> Teagasc 1
Ireland -> Teagasc -> PubMed 1
Ireland -> Trinity College Dublin 175
Ireland -> Trinity College Dublin -> PubMed 83
Ireland -> University College Dublin 1
Ireland -> University College Dublin -> PubMed 1
25-Mar-2010

COMPOSITIONS AND METHODS FOR MODULATING TOLL-LIKE RECEPTOR ACTIVITY
+
26-Oct-2006

POLYPEPTIDES AND USE THEREOF
+
15-Apr-2004

ORTHOPOXVIRUS VECTORS, GENES AND PRODUCTS THEREOF
+
18-Mar-2004

ORTHOPOXVIRUS VECTORS, GENES AND PRODUCTS THEREOF
+

  1. Further insights

    Clicking through these tabs will give you a wealth of further insights into this expert through their commonly used topics, the evolution of their expertise, their collaborators and their publications.

  2. Details

    Here is a quick breakdown of this expert's publication history

  3. Contact

    If this is the expert you have been looking for, simply click here to make contact.